研究論文一覧

1. C.J. Glueck, P. Wang, S. Kobayashi, H. Phillips, L. Sieve-Smith. Metformin therapy throughout pregnancy reduces the development of gestational diabetes in women with polycystic ovary syndrome. Fertil Steril 77(3):520-5, 2002

2. D. Beitner-Johnson, T. Fergusson, R.T. Rust, S. Kobayashi, D.E. Millhorn. Calcium-dependent activation of Pyk2 by hypoxia. Cell Signal 14(2): 133-37, 2001

3. D. Beitner-Johnson, K. Seta, Y. Yuan, H. Kim, R.T. Rust, P.W. Conrad, S. Kobayashi, D.E. Millhorn. Identification of hypoxia-responsive genes in a dopaminergic cell line by substractive cDNA libraries and microarray analysis. Parkinsonism Relat Disord 7(3): 273-281, 2001

4. S. Kobayashi, D.E. Millhorn. Hypoxia regulates glutamate metabolism and membrane transport in rat PC12 cells. J Neurochem 76(6): 1935-48, 2001

5. P.W. Conrad PW, L. Conforti L, S. Kobayashi, D. Beitner-Johnson, R.T. Rust, Y. Yuan, H. Kim, R.H. Kim, K. Seta, D.E. Millhorn. The molecular basis of 2-sensing and hypoxia tolerance in pheochromocytoma cells. Comp Biochem Physiol B Biochem Mol Biol 128(2): 187-204, 2001

6. S. Kobayashi, L. Conforti, D.E. Millhorn. Gene expression and function of adenosine A2A receptor in the rat carotid body. Am J Physiol Lung Cell Mol Physiol 279(2): L273-82, 2000

7. D.E. Millhorn, Betner-Johnson D, L. Conforti, P.W. Conrad, S. Kobayashi, Y. Yuan, R. Rust. Gene regulation during hypoxia in excitable oxygen-sensing cells: depolarization-transcription coupling. Adv Exp Med Biol 475: 131-142, 2000

8. S. Kobayashi, H. Zimmermann, D.E. Millhorn. Chronic hypoxia enhances adenosine release in rat PC12 cells by altering adenosine metabolism and membrane transport. J Neurochem 74(2): 621-32, 2000

9. S. Kobayashi, D.E. Millhorn. Regulation of N-methyl-D-aspartate receptor expression and N-methy;-D-aspartate-induced cellular response during chronic hypoxia in differentiated rat PC12 cells. Neuroscience 101(4): 1153-62, 2000

10. S. Kobayashi, L. Conforti, W.H. Zhu, D. Beiter-Johnson, D.E. Millhorn. Role of the D2 dopamine receptor in molecular adaptation to chronic hypoxia in PC12 cells. Pfugers Arch 438(6): 750-9, 1999

11. S. Kobayashi, D.E. Millhorn. Stimulation of gene expression for the adenosine A2A receptor by hypoxia in PC12 cells: a potential role in cell protection. J Biol Chem 274(29): 20358-65

12. S. Kobayashi, D. Beitner-Johnson, L. Conforti, D.E. Millhorn. Chronic hypoxia reduces adenosine A2A receptor mediated membrane current via down-regulation of protein kinase A in PC12 cells. J Physiol, London 512.2: 351-363, 1998

13. S. Kobayashi, L. Conforti, R. Pun, D.E. Millhorn. Adenosine modulates hypoxia-induced responses rat PC12 cells via the A2A receptor. J Physiol, London 508. 1, 95-107, 1998

14. S. Kobayashi. Control of breathing (in Japanese). Molecular Biology of Lung Disease, edited by Y. kawakami et al., 196-201, Igaku-shoin, Tokyo, 1998

15. L. Conforti, W.H.Zhu, S. Kobayashi, D.E.Millhorn. Mechanisms of oxygen chemosensitivity in a model cell line system. In Oxygen regulation of ion channels and gene expression. Edited by J. Lopez-Barneo and E.K. Weir by Futura Publishing Co. Armonk NY, 181-192, 1998

16. L. Conforti, S. Kobayashi, D. Beitner-Johnson, P.W. Conrad, T. Freeman, D.E. Millhorn. Regulation of gene expression and secretory functions in oxygen-sensing pheochromocytoma cells. Resp Physiol 1115(2): 249-60, 1999

17. D.E. Millhorn, R. Raymond, L. Conforti, W. Zhu, D. Beitner-Johnson, T. Filisko, M.B. Genter, S. Kobayashi, M. Peng. Regulation of gene expression for tyrosine hydroxylase in oxygen sensitive cells by hypoxia. Kid Int 51(2):527-35, 1997

18. S. Kobayashi. Control of breathing in endocrine/metabolic disorders (in Japanese). Control of breathing: clinical application, edited by Y. Kawakami, 262-272, Bunkodo Press, Tokyo, 1997

19. D.E. Millhorn, L. Conforti, D. Beitner-Johnson, WH Zhu, R. Raymond, T. Filisko, S. Kobayashi, M. Peng, M.B. Genter. Regulation of ionic conductances and gene expression by hypoxia in an oxygen sensitive cell line. Adv Exp Med Biol 410: 135-42, 1996

20. S. Kobayashi, M. Nishimura, M. Yamamoto, Y. Akiyama, K. Miyamoto, Y. Kawakami. Relation between dyspnea sensation on hypoxic and hypercapnic ventilatory response in patients with COPD. Eur Resp J 9. 2340-2345, 1996

21. Y. Akiyama, M. Nishimura, S. Kobayashi, M. Yamamoto, K. Miyamoto, Y. Kawakami. Effects of M1-selective antimuscarinics on respiratory chemosensitivity in humans. Resp Physiol 103(2):127-35, 1996

22. S. Kobayashi, M. Nishimura, H. Taguchi, K. Miyamoto, Y. Kawakami. Effect of octreotide on ventilation and dyspnea sensation in cirrhotic hypoxemia. Int Med 34, 5, 401-405, 1995

23. T. Igarashi, M. Nishimura, S. Kobayashi, K. Miyamoto, Y. Kawakami. Dependency on the rate of change in PaO2 of the ventilatory response to progressive hypoxia. Am J Resp Crit Care Med 151(6):1815-20, 1995

24. Y. Nasuhara, S. Kobayashi, M. Munakata, Y. Kawakami, M. Fujita. A case of mycosis fungoides with pulmonary involvement: effect of etoposide and prednisolone (in Japanese). Jap J Resp Dis 33(9):1013-8, 1995

25. S. Kobayashi, M. Nishimura, K. Miyamoto, Y. Kawakami. Attenuation of hypoxic ventilatory response after recovery from chronic hypoxemia in a case of pulmonary AV fistula. Eur Resp J 7, 2085-2088, 1994

26. S. Kobayashi, M. Nishimura, Y. Nasuhara, K. Miyamoto, Y. Kawakami. A case of pulmonary AV fistula: possible role of adenosine in hyperventilation. Am J Resp Crit Care Med 150, 1718-1721, 1994

27. S. Kobayashi, M. Nishimura, M. Yamamoto, Y. Akiyama, K. Miyamoto, Y. Kawakami. Respiratory load compensation in patients with pulmonary emphysema. Chest 105, 1399-1405, 1994

28. M. Yamamoto, M. Nishimura, S. Kobayashi, Y. Akiyama, K. Miyamoto, Y. Kawakami. Role of endogenous adenosine in hypoxic ventilatory response in humans; a study with dipyridamole. J Appl Physiol 76(1):196-203, 1994

29. A. Hasegawa, M. Ohe, K. Yamazaki, S. Kobayashi, M. Munakata, Y. Kawakami. A rare case of Young’s syndrome in Japan. Int Med 33(10):649-53, 1994

30. S. Kobayashi, M. Nishimura, M. Yamamoto, Y. Akiyama, F. Kishi, Y. Kawakami. Dyspnea sensation and chemical control of breathing in adult twins. Am Rev Resp Dis 147, 1192-1198, 1993

31. S. Kobayashi, A. Aida, K. Aoi, M. Nishimura, Y. Kawakami. A case of liver cirrhosis with severe ypoxemia and paradoxical pulmonary vascular response to graded inspiratory oxygen tension. Chest 103, 958-960, 1993

32. Y. Akiyama, M. Nishimura, S. Kobayashi, A. Yoshioka, M. Yamamoto, K. Miyamoto, Y. Kawakami. Effects of naloxone on the sensation of dyspnea during acute respiratory stress in normal adults. J Appl Physiol 74(2):590-5, 1993

33. Y. Akiyama, M. Nishimura, S. Kobayashi, M. Yamamoto, K. Miyamoto, Y. Kawakami. Effects of aging on respiratory load compensation and dyspnea sensation. Am Rev Resp Dis 148(6):1586-91, 1993

34. S. Kobayashi, Y. Yoshida, M. Nishimura, K. Miyamoto, Y. Kawakami. Paradoxical bradycardia during exercise and hypoxic exposure - the possible direct effect of hypoxia on sinoatrial node activity in humans. Chest 102, 1893-1895, 1992

35. S. Kobayashi, M. Nishimura, M. Yamamoto, Y. Akiyama, K. Miyamoto, Y. Kawakami. Role of psychological factors as a determinant of the hypercapnic ventilatory response and dyspnea sensation (in Japanese). Jap J Resp Dis 30(6), 1042-1049, 1992

36. S. Kobayashi, M. Nishimura, M. Yamamoto, Y. Akiyama, K. Miyamoto, Y. Kawakami. Effect of hypoxia on the sensation of dyspnea during hypercapnic ventilatory response in normal subjects (in Japanese). Jap J Resp Dis 30(7), 1207-1214, 1992

37. M. Nishimura, Y. Akiyama, S. Kobayashi, M. Yamamoto, Y. Kawakami. Effects of aging on control of breathing (in Japanese). Jap J Resp Dis 30(2):168-74, 1992

38. Y. Kawakami, S. Kobayashi, M. Yamamoto, Y. Akiyama, M. Nishimura. Relation between dyspnea and personality in patients with pulmonary emphysema and healthy subjects (in Japanese). Jap J Resp Dis 30(4):561-6, 1992

39. M. Nishimura, A. Kakinoki, S. Kobayashi, M. Yamamoto, Y. Akiyama, K. Miyamoto, Y. Kawakami. Effect of theophylline on brain acid-base status during normoxia and hypoxia in humans. Control of breathing and its modeling perspectives, edited by Y. Honda et al., pp225-228, Plenum Press, New York, 1992

40. Y. Akiyama, M. Nishimura, S. Kobayashi, M. Yamamoto, K. Miyamoto, Y. Kawakami. Dyspnea and respiratory compensation response to resistive loading in elderly humans. Control of breathing and its modeling perspectives, edited by Y. Honda et al., pp167-170, Plenum Press, New York, 1992

41. M. Nishimura, T. Kusaka, S. Kobayashi, M. Yamamoto, Y. Akiyama, Y. Kawakami. Analysis of dysnapsis in healthy twins and sons of patients with chronic obstructive lung disease (in Japanese). Jap J Respir Dis 29(1):40-5, 1991

42. Y. Kawakami, M. Nishimura, S. Kobayashi, Y. Akiyama. Genetic influence on personality, thresholds for added resistance and dyspnea sensation. Control of Breathing and Dyspnea, T. Takishima & N.S. Cherniack editors, Pergamon Press, Oxford, pp329-335, 1991

43. S. Kobayashi, Y. Kawakami, T. Hirabayashi. ACE inhibitors and cough (in Japanese). Kokyu to Junkan - 38(8):763-7, 1990

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